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Effectiveness of Weight Loss Interventions and Mortality Risk

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  1. Lammert O, Grunnet N, Faber P, Bjørnsbo KS, Dich J, Larsen LO, et al. Effects of isoenergetic overfeeding of either carbohydrate or fat in young men. Br J Nutr. 2000;84(2):233–45.
  2. Hall KD, Guo J. Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition. Gastroenterology. 2017;152(7):1718–27.
  3. Hall KD, Bemis T, Brychta R, Chen KY, Courville A, Crayner EJ, et al. Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity. Cell Metab. 2015;22(3):427–36.
  4. Swinburn BA, Sacks G, Lo SK, Westerterp KR, Rush EC, Rosenbaum M, et al. Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am J Clin Nutr. 2009 Jun 1;89(6):1723–8.
  5. Feinman RD, Fine EJ. Thermodynamics and Metabolic Advantage of Weight Loss Diets. Metab Syndr Relat Disord. 2003 Sep;1(3):209–19.
  6. Manninen AH. Is a Calorie Really a Calorie? Metabolic Advantage of Low-Carbohydrate Diets. J Int Soc Sports Nutr. 2004 Dec 1;1(2):21-26.
  7. Ebbeling CB, Feldman HA, Klein GL, Wong JMW, Bielak L, Steltz SK, et al. Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial. BMJ. 2018;363:k4583.
  8. Franz MJ, VanWormer JJ, Crain AL, Boucher JL, Histon T, Caplan W, et al. Weight-Loss Outcomes: A Systematic Review and Meta-Analysis of Weight-Loss Clinical Trials with a Minimum 1-Year Follow-Up. J Am Diet Assoc. 2007 Oct;107(10):1755–67.
  9. Hall KD, Kahan S. Maintenance of Lost Weight and Long-Term Management of Obesity. Medical Clinics of North America. 2018 Jan;102(1):183–97.
  10. Anderson JW, Konz EC, Frederich RC, Wood CL. Long-term weight-loss maintenance: a meta-analysis of US studies. Am J Clin Nutr. 2001 Nov 1;74(5):579–84.
  11. Sørensen TIA, Rissanen A, Korkeila M, Kaprio J. Intention to Lose Weight, Weight Changes, and 18-y Mortality in Overweight Individuals without Co-Morbidities. PLoS Med. 2005 Jun 28;2(6):e171.
  12. Sorensen TIA. Weight loss causes increased mortality: pros. Obesity Reviews. 2003 Feb;4(1):3–7.
  13. Schvey NA, Puhl RM, Brownell KD. The stress of stigma: Exploring the effect of weight stigma on cortisol reactivity. Psychosom Med. 2014;76(2):156–62.
  14. Puhl RM, Heuer CA. Obesity Stigma: Important Considerations for Public Health. Am J Public Health. 2010 Jun;100(6):1019–28.
  15. Palascha A, van Kleef E, van Trijp HCM. How does thinking in Black and White terms relate to eating behavior and weight regain? J Health Psychol. 2015;20(5):638–48.
  16. Dulloo AG, Montani JP. Pathways from dieting to weight regain, to obesity and to the metabolic syndrome: An overview. Obesity Reviews. 2015;16(S1):1–6.
  17. MacLean PS, Bergouignan A, Cornier MA, Jackman MR. Biology’s response to dieting: the impetus for weight regain. AJP: Regulatory, Integrative and Comparative Physiology. 2011;301(3):R581–600.
  18. Group TLAR. Eight-Year Weight Losses with an Intensive Lifestyle Intervention: The Look AHEAD Study. Obesity. 2014;22(1):5–13.
  19. Stampfer M. Weight Loss and Mortality: What Does the Evidence Show? PLoS Med. 2005 Jun 28;2(6):e181.
  20. French SA, Jejfery RW, Folsom AR, Williamson DF, Byers T. History of Intentional and Unintentional Weight Loss in a Population-Based Sample of Women Aged 55 to 69 Years. Obes Res. 1995 Mar;3(2):163–70.
  21. Astrup A. Weight loss and increased mortality: epidemiologists blinded by observations? Obesity Reviews. 2003 Feb;4(1):1–2.
  22. Yang D, Fontaine KR, Wang C, Allison DB. Weight loss causes increased mortality: cons. Obesity Reviews. 2003 Feb;4(1):9–16.
  23. Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, et al. Intentional Weight Loss and All-Cause Mortality: A Meta-Analysis of Randomized Clinical Trials. PLoS One. 2015 Mar 20;10(3):e0121993.
  24. Amati F, Banks C, Greenfield G, Green J. Predictors of outcomes for patients with common mental health disorders receiving psychological therapies in community settings: a systematic review. J Public Health (Bangkok). 2018 Sep 1;40(3):e375–87.
  25. Group LAR. The Look AHEAD Study: A Description of the Lifestyle Intervention and the Evidence Supporting It. Obesity. 2006;14(5):737–52.
  26. Wadden TA, Neiberg RH, Wing RR, Clark JM, Delahanty LM, Hill JO, et al. Four-year weight losses in the look AHEAD study: Factors associated with long-term success. Obesity. 2011;19(10):1987–98
  27. Ayyad C, Anderson T. Long-term efficacy of dietary treatment of obesity: a systematic review of studies published between 1931 and 1999. Obes Res Clin Pract. 2000;1:113-119-.
  28. Golzarand M, Toolabi K, Farid R. The bariatric surgery and weight losing: a meta-analysis in the long- and very long-term effects of laparoscopic adjustable gastric banding, laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy on weight loss in adults. Surg Endosc. 2017 Nov 4;31(11):4331–45.
  29. Wilding JPH, Batterham RL, Calanna S, Davies M, van Gaal LF, Lingvay I, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine. 2021 Mar 18;384(11):989–1002.