« Back to Research Deepdives

Linoleic Liver: Can Omega-6 PUFA Protect Against Fatty Liver?

This content is restricted to members.

To view our premium content, sign up for a membership:


Register New Account

Choose your membership level

Choose Your Payment Method

‹ Back to Research Deepdives


1. Green C, Hodson L. The Influence of Dietary Fat on Liver Fat Accumulation. Nutrients. 2014;6(11):5018-5033.
2. Luukkonen P, Sadevirta S, Zhou Y, Ali A, Ahonen L, Lallukka S et al. Saturated fat is more metabolically harmful for the human liver than polyunsaturated fat or simple sugars. Journal of Hepatology. 2018;68:S836.
3. Summers L, Fielding B, Bradshaw H, Ilic V, Beysen C, Clark M et al. Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity. Diabetologia. 2002;45(3):369-377.
4. Bjermo H, Iggman D, Kullberg J, Dahlman I, Johansson L, Persson L et al. Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial. The American Journal of Clinical Nutrition. 2012;95(5):1003-1012.
5. Green C, Pramfalk C, Charlton C, Gunn P, Cornfield T, Pavalides M et al. Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism. BMJ Open Diabetes Research & Care. 2020;8(1):e000871.
6. Bergeron N, Havel R. Influence of Diets Rich in Saturated and Omega-6 Polyunsaturated Fatty Acids on the Postprandial Responses of Apolipoproteins B-48, B-100, E, and Lipids in Triglyceride-Rich Lipoproteins. Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15(12):2111-2121.
7. Rett B, Whelan J. Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review. Nutrition & Metabolism. 2011;8(1):36.
8. Johnson G, Fritsche K. Effect of Dietary Linoleic Acid on Markers of Inflammation in Healthy Persons: A Systematic Review of Randomized Controlled Trials. Journal of the Academy of Nutrition and Dietetics. 2012;112(7):1029-1041.e15.