« Back to Research Deepdives

Does Intermittent Fasting Improve Glycaemic Control in Type-2 Diabetes?

This content is restricted to members.

To view our premium content, sign up for a membership:


Register New Account

Choose your membership level

Choose Your Payment Method

‹ Back to Research Deepdives


  1. Alhamdan BA, Garcia-Alvarez A, Alzahrnai AH, Karanxha J, Stretchberry DR, Contrera KJ, et al. Alternate-day versus daily energy restriction diets: which is more effective for weight loss? A systematic review and meta-analysis. Obes Sci Pract. 2016;2(3):293–302.
  2. Elortegui Pascual P, Rolands MR, Eldridge AL, Kassis A, Mainardi F, Lê K, et al. A meta‐analysis comparing the effectiveness of alternate day fasting, the 5:2 diet, and time‐restricted eating for weight loss. Obesity. 2023 Feb 8;31(S1):9–21.
  3. Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab. 2018;27(6):1212-1221.e3.
  4. Chaix A, Zarrinpar A, Miu P, Panda S. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab. 2014;20(6):991–1005.
  5. Sherman H, Genzer Y, Cohen R, Chapnik N, Madar Z, Froy O. Timed high‐fat diet resets circadian metabolism and prevents obesity. The FASEB Journal. 2012 Aug 16;26(8):3493–502.
  6. Schroor MM, Joris PJ, Plat J, Mensink RP. Effects of Intermittent Energy Restriction Compared with Those of Continuous Energy Restriction on Body Composition and Cardiometabolic Risk Markers – A Systematic Review and Meta-Analysis of Randomized Controlled Trials in Adults. Advances in Nutrition. 2024 Jan;15(1):100130.
  7. Douketis JD, Macie C, Thabane L, Williamson DF. Systematic review of long-term weight loss studies in obese adults: clinical significance and applicability to clinical practice. Int J Obes. 2005 Oct 5;29(10):1153–67.
  8. Blackburn G. Effect of Degree of Weight Loss on Health Benefits. Obes Res. 1995 Sep 6;3(S2).
  9. Jamshed H, Beyl RA, Manna DLD, Yang ES, Ravussin E, Peterson CM. Early time-restricted feeding improves 24-hour glucose levels and affects markers of the circadian clock, aging, and autophagy in humans. Nutrients. 2019;11(6):3–5.
  10. Qian J, Dalla Man C, Morris CJ, Cobelli C, Scheer FAJL. Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans. Diabetes Obes Metab. 2018;20(10):2481–5.
  11. Morris CJ, Yang JN, Garcia JI, Myers S, Bozzi I, Wang W, et al. Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans. Proc Natl Acad Sci U S A. 2015;112(17):E2225–34.
  12. Cauter E Van, Désir D, Decoster C, Féry F, Balasse EO. Nocturnal Decrease in Glucose Tolerance During Constant Glucose Infusion. Journal of Clinical Endocrinology and Metabolism. 1989;69(3):604–11.
  13. Jakubowicz D, Wainstein J, Ahren B, Landau Z, Bar-Dayan Y, Froy O. Fasting until noon triggers increased postprandial hyperglycemia and impaired insulin response after lunch and dinner in individuals with type 2 Diabetes: A randomized clinical trial. Diabetes Care. 2015;38(10):1820–6.
  14. Jakubowicz D, Wainstein J, Ahrén B, Bar-Dayan Y, Landau Z, Rabinovitz HR, et al. High-energy breakfast with low-energy dinner decreases overall daily hyperglycaemia in type 2 diabetic patients: a randomised clinical trial. Diabetologia. 2015;58(5):912–9.
  15. Jovanovic A, Gerrard J, Taylor R. The second-meal phenomenon in type 2 diabetes. Diabetes Care. 2009;32(7):1199–201.