« Back to Research Deepdives

Regulating Food Cravings: What Does the Brain Say?

This content is restricted to members.

To view our premium content, sign up for a membership:


Register New Account

Choose your membership level

Choose Your Payment Method

‹ Back to Research Deepdives


  1. Kennedy, G. C. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond B Biol Sci . 195 Jan;140(901):578–596.
  2. Hervey, G. R. (1959). The effects of lesions in the hypothalamus in parabiotic rats. J Physiol. 1959 Mar;145(2):336–352..
  3. Li G, Hu Y, Zhang W, Wang J, Ji W, Manza P, et al. Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions. Mol Psychiatry. 2023 Apr 14;28(4):1466–79.
  4. Boswell RG, Kober H. Food cue reactivity and craving predict eating and weight gain: a meta-analytic review. Obesity Reviews. 2016 Feb;17(2):159–77.
  5. Potenza MN, Grilo CM. How Relevant is Food Craving to Obesity and Its Treatment? Front Psychiatry. 2014 Nov 19;5.
  6. Lutter M, Nestler EJ. Homeostatic and Hedonic Signals Interact in the Regulation of Food Intake. J Nutr. 2009 Mar;139(3):629–32.
  7. Burger KS, Berner LA. A functional neuroimaging review of obesity, appetitive hormones and ingestive behavior. Physiol Behav. 2014 Sep;136:121–7.
  8. Gupta A, Mayer EA, Hamadani K, Bhatt R, Fling C, Alaverdyan M, et al. Sex differences in the influence of body mass index on anatomical architecture of brain networks. Int J Obes. 2017 Aug 31;41(8):1185–95.
  9. Stice E, Yokum S, Blum K, Bohon C. Weight Gain Is Associated with Reduced Striatal Response to Palatable Food. The Journal of Neuroscience. 2010 Sep 29;30(39):13105–9.
  10. Yokum S, Bohon C, Berkman E, Stice E. Test-retest reliability of functional MRI food receipt, anticipated receipt, and picture tasks. Am J Clin Nutr. 2021 Aug;114(2):764–79.
  11. Volkow ND, Wang GJ, Tomasi D, Baler RD. Obesity and addiction: neurobiological overlaps. Obesity Reviews. 2013 Jan;14(1):2–18.
  12. Berridge KC. ‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders. Physiol Behav. 2009 Jul;97(5):537–50.
  13. Wang GJ, Volkow ND, Logan J, Pappas NR, Wong CT, Zhu W, et al. Brain dopamine and obesity. The Lancet. 2001 Feb;357(9253):354–7.
  14. Stice E, Burger KS, Yokum S. Reward Region Responsivity Predicts Future Weight Gain and Moderating Effects of the TaqIA Allele. Journal of Neuroscience. 2015 Jul 15;35(28):10316–24.
  15. Stice E, Yokum S. Relation of neural response to palatable food tastes and images to future weight gain: Using bootstrap sampling to examine replicability of neuroimaging findings. Neuroimage. 2018 Dec;183:522–31.
  16. Drew Sayer R, Tamer GG, Chen N, Tregellas JR, Cornier M, Kareken DA, et al. Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity. Obesity. 2016 Oct 20;24(10):2057–63.
  17. Bach P, Grosshans M, Koopmann A, Kienle P, Vassilev G, Otto M, et al. Reliability of neural food cue-reactivity in participants with obesity undergoing bariatric surgery: a 26-week longitudinal fMRI study. Eur Arch Psychiatry Clin Neurosci. 2021 Aug 17;271(5):951–62.
  18. Simon JJ, Becker A, Sinno MH, Skunde M, Bendszus M, Preissl H, et al. Neural Food Reward Processing in Successful and Unsuccessful Weight Maintenance. Obesity. 2018 May;26(5):895–902.
  19. Hermann P, Gál V, Kóbor I, Kirwan CB, Kovács P, Kitka T, et al. Efficacy of weight loss intervention can be predicted based on early alterations of fMRI food cue reactivity in the striatum. Neuroimage Clin. 2019;23:101803.