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Is the Effect of Cocoa on Cognition Hidden in the COSMOS?

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  1. Holst B, Williamson G. Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants. Curr Opin Biotechnol. 2008;19(2):73–82.
  2. Scalbert A, Williamson G. Dietary Intake and Bioavailability of Polyphenols. J Nutr. 2000 Aug 1;130(8):2073S-2085S.
  3. Rodriguez-Mateos A, Vauzour D, Krueger CG, Shanmuganayagam D, Reed J, Calani L, et al. Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update. Arch Toxicol. 2014;88(10):1803–53.
  4. Xu Y, Le Sayec M, Roberts C, Hein S, Rodriguez-Mateos A, Gibson R. Dietary Assessment Methods to Estimate (Poly)phenol Intake in Epidemiological Studies: A Systematic Review. Advances in Nutrition. 2021 Sep;12(5):1781–801.
  5. Ottaviani JI, Fong R, Kimball J, Ensunsa JL, Britten A, Lucarelli D, et al. Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies. Sci Rep. 2018 Jun 29;8(1):9859.
  6. Flanagan A, Bradfield J, Kohlmeier M, Ray S. Need for a nutrition-specific scientific paradigm for research quality improvement. BMJ Nutr Prev Health. 2023 Jul 14;e000650.
  7. Morris MC, Tangney CC. A potential design flaw of randomized trials of vitamin supplements. JAMA – Journal of the American Medical Association. 2011;305(13):1348–9.
  8. Kang JH, Cook N, Manson JA, Buring JE, Grodstein F. A randomized trial of vitamin E supplementation and cognitive function in women. Arch Intern Med. 2006;166(22):2462–8.
  9. Brickman AM, Yeung LK, Alschuler DM, Ottaviani JI, Kuhnle GGC, Sloan RP, et al. Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and lower habitual flavanol consumption. Proceedings of the National Academy of Sciences. 2023 Jun 6;120(23).