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EPIC-Oxford: A Deepdive Review of Cancer Incidence in the UK Between Vegetarians and Non-Vegetarians

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  1. Appleby P, Crowe F, Bradbury K, Travis R, Key T. Mortality in vegetarians and comparable nonvegetarians in the United Kingdom. The American Journal of Clinical Nutrition. 2015;103(1):218-230.
    2. Mihrshahi S, Ding D, Gale J, Allman-Farinelli M, Banks E, Bauman A. Vegetarian diet and all-cause mortality: Evidence from a large population-based Australian cohort – the 45 and Up Study. Preventive Medicine. 2017;97:1-7.
    3. Key T, Fraser G, Thorogood M, Appleby P, Beral V, Reeves G et al. Mortality in vegetarians and nonvegetarians: detailed findings from a collaborative analysis of 5 prospective studies. The American Journal of Clinical Nutrition. 1999;70(3):516s-524s.
    4. Orlich M, Singh P, Sabaté J, Jaceldo-Siegl K, Fan J, Knutsen S et al. Vegetarian Dietary Patterns and Mortality in Adventist Health Study 2. JAMA Internal Medicine. 2013;173(13):1230.
    5. Kwok C, Umar S, Myint P, Mamas M, Loke Y. Vegetarian diet, Seventh Day Adventists and risk of cardiovascular mortality: A systematic review and meta-analysis. International Journal of Cardiology. 2014;176(3):680-686.
    6. Willett W. Nutritional epidemiology. New York [etc.]: Oxford University Press; 2013.
    7. Taylor N. In response to the December 2016 article entitled “Vegetarian diet and all-cause mortality: Evidence from a large population-based Australian cohort – the 45 and Up Study”. Preventive Medicine. 2017;100:275-276.
    8. Mozaffarian D. Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity. Circulation. 2016;133(2):187-225.
    9. Fraser G. Associations between diet and cancer, ischemic heart disease, and all-cause mortality in non-Hispanic white California Seventh-day Adventists. The American Journal of Clinical Nutrition. 1999;70(3):532s-538s.
    10. Key T, Appleby P, Crowe F, Bradbury K, Schmidt J, Travis R. Cancer in British vegetarians: updated analyses of 4998 incident cancers in a cohort of 32,491 meat eaters, 8612 fish eaters, 18,298 vegetarians, and 2246 vegans. The American Journal of Clinical Nutrition. 2014;100(suppl_1):378S-385S.
    11. Key T, Appleby P, Spencer E, Travis R, Roddam A, Allen N. Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford). The American Journal of Clinical Nutrition. 2009;89(5):1620S-1626S.
    12. Bouvard V, Loomis D, Guyton K, Grosse Y, Ghissassi F, Benbrahim-Tallaa L et al. Carcinogenicity of consumption of red and processed meat. The Lancet Oncology. 2015;16(16):1599-1600.
    13. Rohrmann S, Overvad K, Bueno-de-Mesquita H, Jakobsen M, Egeberg R, Tjønneland A. Meat consumption and mortality — Results from the European prospective investigation into cancer and nutrition. BMC Medicine. 2013;11(S. Rohrmann, K. Overvad, H.B. Bueno-de-Mesquita, M.U. Jakobsen, R. Egeberg, A. Tjønneland,):63.
    14. Turner N, Lloyd S. Association between red meat consumption and colon cancer: A systematic review of experimental results. Experimental Biology and Medicine. 2017;242(8):813-839.
    15. Pierre F, Martin O, Santarelli R, Tache S, Naud N, Gueraud F et al. Calcium and -tocopherol suppress cured-meat promotion of chemically induced colon carcinogenesis in rats and reduce associated biomarkers in human volunteers. American Journal of Clinical Nutrition. 2013;98(5):1255-1262.
    16. Mirvish S. Effects of vitamins C and E on N-nitroso compound formation, carcinogenesis, and cancer. Cancer. 1986;58(S8):1842-1850.
    17. Bastide N, Chenni F, Audebert M, Santarelli R, Tache S, Naud N et al. A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake. Cancer Research. 2015;75(5):870-879.
    18. Aune D, Chan D, Lau R, Vieira R, Greenwood D, Kampman E et al. Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. BMJ. 2011;343(nov10 1):d6617-d6617.
    19. Ou J, Carbonero F, Zoetendal E, DeLany J, Wang M, Newton K et al. Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans. American Journal of Clinical Nutrition. 2013;98(1):111-120.
    20. O’Keefe S, Li J, Lahti L, Ou J, Carbonero F, Mohammed K et al. Fat, fibre and cancer risk in African Americans and rural Africans. Nature Communications. 2015;6:6342.
    21. Davey G, Spencer E, Appleby P, Allen N, Knox K, Key T. EPIC–Oxford:lifestyle characteristics and nutrient intakes in a cohort of 33 883 meat-eaters and 31 546 non meat-eaters in the UK. Public Health Nutrition. 2003;6(3):259-268.
    22. Appleby P, Thorogood M, Mann J, Key T. The Oxford Vegetarian Study: an overview. The American Journal of Clinical Nutrition. 1999;70(3):525s-531s.
    23. Papier K, Tong T, Appleby P, Bradbury K, Fensom G, Knuppel A et al. Comparison of Major Protein-Source Foods and Other Food Groups in Meat-Eaters and Non-Meat-Eaters in the EPIC-Oxford Cohort. Nutrients. 2019;11(4):824.
    24. Mealing N, Banks E, Jorm L, Steel D, Clements M, Rogers K. Investigation of relative risk estimates from studies of the same population with contrasting response rates and designs. BMC Medical Research Methodology. 2010;10(1).
    25. Archer E, Pavela G, Lavie C. The Inadmissibility of What We Eat in America and NHANES Dietary Data in Nutrition and Obesity Research and the Scientific Formulation of National Dietary Guidelines. Mayo Clinic Proceedings. 2015;90(7):911-926.
    26. Beaton G, Burema J, Ritenbaugh C. Errors in the interpretation of dietary assessments. The American Journal of Clinical Nutrition. 1997;65(4):1100S-1107S.
    27. Subar A, Freedman L, Tooze J, Kirkpatrick S, Boushey C, Neuhouser M et al. Addressing Current Criticism Regarding the Value of Self-Report Dietary Data. The Journal of Nutrition. 2015;145(12):2639-2645.
    28. Wrieden W, Barton K. Calculation and Collation of Typical Food Portion Sizes for Adults Aged 19-64 and Older People Aged 65 and Over. The Food Standards Agency; 2006 p. 1-24.
    29. Vulcan A, Manjer J, Ericson U, Ohlsson B. Intake of Different Types of Red Meat, Poultry and Fish and Incident Colorectal Cancer in Women and Men – Results from the Malmö Diet and Cancer Study. Clinical Nutrition. 2016;35:S30-S31.
    30. Sobiecki J. Vegetarianism and colorectal cancer risk in a low-selenium environment: effect modification by selenium status? A possible factor contributing to the null results in British vegetarians. European Journal of Nutrition. 2017;56(5):1819-1832.
    31. Rayman M. Selenium and human health. The Lancet. 2012;379(9822):1256-1268.
    32. Hughes D, Fedirko V, Jenab M, Schomburg L, Méplan C, Freisling H et al. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. International Journal of Cancer. 2014;136(5):1149-1161.
    33. Domingo J, Nadal M. Carcinogenicity of consumption of red meat and processed meat: A review of scientific news since the IARC decision. Food and Chemical Toxicology. 2017;105:256-261.
    34. Kappeler R, Eichholzer M, Rohrmann S. Meat consumption and diet quality and mortality in NHANES III. European Journal of Clinical Nutrition. 2013;67(6):598-606.